“Breaking News”

· Our analysis of ion binding pattern in HHR, based on the trajectories of total 1.5 microseconds, has been accepted by “J. Mol. Biol”.

· The prediction of an alternative splicing of BCR-ABL (35INS) has been clinically confirmed by Quest scientists and makes the cover story of the current issue of “Mol Cancer Ther” and has been introduced by a news article.

· The manuscript of simulations on WT and V617F of JAK2 has been accepted by the journal “Cancer”.

· Our hammerhead ribozyme makes the cover of “Chemistry & Biology”

· We got another BICB seed grant for 2008-2010 (New Models for Cancer Targets from Clinical Data)!

Movies (be sure you have a high-speed internet connection before watching)

The MD simulation set up for the hammerhead ribozyme with the active site demonstrated.

The proton transfer from G8:O2’ to the leaving group O5, assisted by the Mg2+ ion.   Observed in the QM/MM simulation of the late-transition state of HHR.

The 300ns simulations of HHR in different states (coming soon).

The dynamic behavior of JAK2 wt and V617F (coming soon).